What is vaginal atrophy?
The vaginal system is perhaps the most complex organ of the female body as it includes the simultaneous function of not only the genital but also the urinary and digestive systems.
In detail, on the anterior surface of the vagina is the bladder and urethra, on its bottom is the cervix and on its posterior part is the descending part of the intestine. Phylogenetically, the largest part of it (about 9/10) comes from the embryonic mesoderm, while the last part, like the entrance (forehead of the colon together with the hymen) and the labia majora, come from the embryonic ectoderm .
The importance of this differentiation in origin is of great importance in the functionality as well as in the damage it undergoes over time and also in the change of hormones in menopause, whether this occurs pharmacologically in diseases or physiologically with age.
More specifically, the cells of the vagina, which are flat on the outside and cylindrical on the bottom, must have a relatively acidic PH (3.5-5.2) for it to function smoothly without disturbances and to achieve a normal microbial flora. The basic nutrient stimulus for the smooth functioning of the vagina is the high estrogenic action that occurs when the woman has a regular period and produces estradiol E2.
What are the stages of vaginal atrophy?
On the contrary, in menopause, when hormone production stops for the most part, as in medical menopause, where drugs or surgical techniques stop the period (e.g. in breast, ovarian, cervical cancer, lymphomas or PIF premature ovarian failure) we observe a disorder in the sinus structures, sometimes gradual and sometimes rapid. These modifications, which also create discomfort or ailments in women, have exactly to do with the hormonal complications caused to the vaginal epithelia.
Initially, the vagina loses elasticity and the ability to produce collagen as a result of which it dries out, thins and due to the drop in estrogen, its flora is damaged at the same time as its PH changes (alkalization 6-7). Inflammation and unpleasant odors are often caused, as well as the onset of the feeling of dryness and difficulty in achieving sexual intercourse, which is also combined with reduced desire (decrease in libido).
Then, gradually, we have a loss of hydration of the vaginal lumen that concerns both its interior and more its entrance, resulting in more dryness and atrophy with thinning of the tissues, which implies dyspareunia (ie pain during sex).
Finally, in more advanced stages of atrophy, the vessels and nerves of the vagina are lost, with the result that sensitivity is greatly reduced, the entrance and internal walls narrow and the genitourinary syndrome of GSM menopause occurs, which includes urinary infections, severe dryness and burning, dyspareunia and in general, it is a particularly disturbing situation, since it affects the daily life and destroys the quality of life and the health of the patients.
The wear and tear of the vagina and its problematic function clearly occurs sometimes in women with normal periods, usually from 30-35 years of age and after several years of sexual contact, after normal childbirth and after chronic inflammations and antibiotics that destroy the flora . In these cases, combinations of pathologies such as relaxation on contact, urination disorders and loss of urine, excessive fluids and unpleasant chronic odor are presented.